Since then, Costa Rican President Laura Chinchilla and El Salvador's President Mauricio Funes have said they're open to the discussion, while Panama's leaders say they do not agree with decriminalizing drugs.

For decades Latin Americans leaders and the U.S. have cooperated on a war on drugs, with more than a trillion dollars spent by the U.S. to support enforcement and eradication in Latin America, as well as promises to reduce cocaine, marijuana and methamphetamine use in the U.S. that generates an estimated $25 billion in profits each year.

But during that time, demand for drugs has increased, fueling violent competition between dealers.

In 2009, former presidents of Mexico, Brazil and Colombia blasted the war on drugs and said it was time to consider the decriminalization of marijuana.